(R)-Lansoprazole Dexlansoprazole CAS 138530-94-6 Assay 98.0~102.0% (HPLC) Factory

Short Description:

Chemical Name: (R)-Lansoprazole

Synonyms: Dexlansoprazole 

CAS: 138530-94-6

Assay: 98.0~102.0% (HPLC, %w/w)  

Appearance: White to Off-White Crystalline Powder 

E-Mail: alvin@ruifuchem.com


Product Detail

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Description:

Chemical Properties:

Chemical Name (R)-Lansoprazole
Synonyms R-(+)-Lansoprazole; Dexlansoprazole; 2-[(R)-[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole; T 168390; TAK 390; Lansoprazole Impurity 14; Dexlansoprazole Related Impurities 2; (R)-2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-Benzimidazole;
CAS Number 138530-94-6
CAT Number RF-PI1916
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C16H14F3N3O2S
Molecular Weight 369.36
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White to Off-White Crystalline Powder
Solubility Soluble in Dimethylformamide, Almost Insoluble in Water
Clarity&Colour of Solution Meets the Requirement
Identification IR The infrared absorption spectrum should be consistent with the reference substance
Identification HPLC The retention time of the main peak should be consistent with that of the reference
Specific Rotation +142.0°~+149.0°
Melting Point ~140.0℃
Water Content (K.F) <1.00%
Residue on Ignition <0.10%
Related Impurities (HPLC)
Nitrogen Oxides <0.10%
Sulfone <0.40%
Sulfide <0.20%
Any Other Single Impurity <0.10%
Total Impurities <0.60%
Optical Purity (HPLC) >99.5%
Assay 98.0~102.0% (HPLC, %w/w, on anhydrous basis, solvent-free) 
Heavy Metals <10ppm
Residual Solvents  
Toluene <890ppm
n-Heptane <5000ppm
Bacterial Endotoxin <2.5EU/mg
Test Standard USP Standard; Chinese Pharmacopoeia
Usage API; An Orally Active Proton Pump Inhibitor

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

1

FAQ:

Application:

(R)-Lansoprazole (CAS: 138530-94-6) is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Dexlansoprazole for Lansoprazole dextroisomer, is a kind of anti peptic ulcer drugs for substituted benzimidazole derivatives, in the molecular structure into the element fluorine, second proton pump inhibitors omeprazole after. Dexlansoprazole has the effect of inhibiting the secretion of gastric acid, the effect is better than that of other drugs (Omeprazole, Pantoprazole, Rebela, Tetrazolium) can significantly inhibit the occurrence of ulcer. It is superior to famotidine or Omeprazole for the damage of alcohol induced gastric mucosa and duodenal ulcer mainly caused by acid hypersecretion. In addition, the product has the same anti Helicobacter pylori effect as the bismuth preparation, and is used for reflux esophagitis and Zhuo AI syndrome. Takeda Pharmaceuticals received approval of dexlansoprazole, a dual release formulation of the (R)-isomer of lansoprazol proton pump inhibitor (PPI) already in the market, from the FDA in January 2009. Dexlansoprazole is a delayed release capsule for the oncedaily, oral treatment of heartburn associated with symptomatic non-erosive gastroesophageal reflux disease (GERD), the healing of erosive esophagitis (EE) and the maintenance of healed EE.

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